Would you make the storage of the settings pluggable? Would you consider using LDAP as your store?
PCs and servers set up within a large (or small) organisation may be best served by keeping the configuration in an LDAP enabled directory (eg OpenLDAP). It's a standards based replicable directory. The administrator doesn't have to go to a machine or even connect to a machine to configure it.
It may also make sense to incorporate the possiblity of configuring other devices. Eg Unix servers, Windows servers and workstations, printers, etc) from the same console/store.