pycms is a minimalist component-based Web Content Management System based on CherryPy. It has most of the goodies of Plone/Zope: Python instead of a PHP security mess, no MySQL can of worms, clean separation of code and content, and the ability to run nicely behind a Web server/cache/load balancer. In addition, it features plain text storage of all site contents and settings in JSON files, effortless theming, and a small memory footprint.
pydance is a dancing game written in Python, formerly named pyDDR. The idea is simple. There's a floor mat with arrows, and the game scrolls arrows up the screen to the beat while playing a song. When the arrows reach the top of the screen (not sooner and not later), the player hits the corresponding arrow on the pad, and given that it's hit on time with the beat, points are scored. Based on how well the dance is put together, s/he is graded at the end of the song. Both keyboard and mat play are supported.
pyDirStat is a small tool to view statistical information about a directory. It will generate a view of all files contained in a directory (and subdirectories) with rectangles. Each rectangular area is proportional to the file sizes. It's useful for viewing disk usage with graphics. It's a non-interactive command-line tool that will generate HTML or SVG or SWF files. On Windows, it also runs as a shell extension.
The pylib library features the popular py.test command line tool for rapidly writing and running tests in Python and py.execnet, a new way to do ad-hoc distribution of Python code to remote processes. py.test runs well on Linux, Windows, and OSX using Python 2.4 through to 2.6. It can distribute a single test run to multiple machines. It is used in many projects, ranging from running tens of thousands of tests integrated with buildbot to a few inlined tests on a command line script.