FLTK (pronounced "fulltick") is a cross-platform C++ GUI toolkit for UNIX/Linux (X11), Microsoft Windows, and Mac OS X. It provides modern GUI functionality without the bloat, and supports 3D graphics via OpenGL and its built-in GLUT emulation. FLTK is designed to be small and modular enough to be statically linked, and also works fine as a shared library. It also includes an excellent UI builder called FLUID that can be used to create applications in minutes.
FXPy is a Python extension module which provides an interface to the FOX cross-platform GUI library. With a few minor exceptions, FXPy provides a complete interface to FOX. FOX is a C++-based toolkit for developing graphical user interfaces easily and effectively, and it runs natively under both Unix/X and Microsoft Windows. Some of the significant features of FOX include a rich set of widgets, powerful but easy-to-use layout managers, extensive support for 3-D modeling using OpenGL or Mesa, drag-and-drop (using the XDND protocol) and a registry for persistent application settings.
GTK, which stands for the Gimp ToolKit, is a library for creating graphical user interfaces. It is designed to be small and efficient, but still flexible enough to allow the programmer freedom in the interfaces created. GTK provides some unique features over standard widget libraries.
Tcl provides a portable scripting environment for Unix, Windows, and Macintosh that supports string processing and pattern matching, native file system access, shell-like control over other programs, TCP/IP networking, timers, and event-driven I/O. Tcl has traditional programming constructs like variables, loops, procedures, namespaces, error handling, script packages, and dynamic loading of DLLs. Tk provides portable GUIs on UNIX, Windows, and Macintosh. A powerful widget set and the concise scripting interface to Tk make it a breeze to develop sophisticated user interfaces.
Tkinter is Python's de facto standard GUI (Graphical User Interface) package. It is a thin object-oriented layer on top of Tcl/Tk. To use Tkinter, you don't need to write Tcl code, but you will need to consult the Tk documentation and occasionally the Tcl documentation (since Tk's low-level event handling mechanism is considered part of Tcl).