Qt is a comprehensive, object-oriented development framework that enables development of high-performance, cross-platform rich-client and server-side applications. When you implement a program with Qt, you can run it on the X Window System (Unix/X11), Apple Mac OS X, and Microsoft Windows NT/9x/2000/XP by simply compiling the source code for the platform you want. Qt is the basis for the KDE desktop environment, and is also used in numerous commercial applications such as Google Earth, Skype for Linux, and Adobe Photoshop Elements.
GTK, which stands for the Gimp ToolKit, is a library for creating graphical user interfaces. It is designed to be small and efficient, but still flexible enough to allow the programmer freedom in the interfaces created. GTK provides some unique features over standard widget libraries.
Urwid is a Python library for making text console applications. It has many features including fluid interface resizing, support for UTF-8 and CJK encodings, standard and custom text layout modes, simple markup for setting text attributes, and a powerful, dynamic list box that handles a mix of widget types. It is flexible, modular, and leaves the developer in control.
U++ is a C++ cross-platform rapid application development suite focused on programmers' productivity without sacrificing runtime performance. Based on strictly deterministic design, it provides a viable alternative to garbage-collected platforms, even for business logic oriented problems.
FLTK (pronounced "fulltick") is a cross-platform C++ GUI toolkit for UNIX/Linux (X11), Microsoft Windows, and Mac OS X. It provides modern GUI functionality without the bloat, and supports 3D graphics via OpenGL and its built-in GLUT emulation. FLTK is designed to be small and modular enough to be statically linked, and also works fine as a shared library. It also includes an excellent UI builder called FLUID that can be used to create applications in minutes.
libTISCH is a framework for easy development of multi-touch applications. It contains tools for video processing, calibration, gesture recognition and, most importantly, a GUI toolkit with widgets that utilize the multi-touch gestures detected by the lower layers. It runs on Linux, Mac OS X, and Windows.