BrowserExpress is a Web-based e-mail client. BrowserExpress provides a Web browser interface to any mail server, giving all your users Web-based e-mail from any Web browser. The BrowserExpress interface is fully customizable to support your branding, banner advertisements, and language choice. BrowserExpress implements POP3, SMTP, LDAP, and MIME standards.
OTRS is a platform independent Web-based help desk system that supports service organization of any kind (e.g. IT service, customer and technical product service, complaint management, public services, etc.) to increase their efficiency. It increases transparency as well as service quality and lowers your total cost of ownership. It has been certified ITIL V3 compatible by PinkVERIFY for incident, problem, change, service asset and configuration, request fulfillment, and knowledge management. Other ITIL processes like service catalog and service level management are supported as well.
PHP Mobile Mail is aimed at mobile professionals who want to use their favorite MUAs (noteably pine or mutt) on their laptop, either in UNIX or Windows (under GNU Gygwin). This lets you work offline. It includes a mail_spooler program, which accepts the output of you MUA and spools (on, or offline). When connected, another process parses through the spool and sends your messages. It is also designed to "fake" using your REAL email address with free services like gmx.net, or mail.yahoo.com, when using their POP and SMTP servers, assuming you have a domain and account that you can control to this degree.
msmtp is an SMTP client with a sendmail compatible interface. It can be used with Mutt and other MUAs. It forwards messages to an SMTP server which does the delivery. Features include various SMTP AUTH methods, TLS/SSL-encrypted connections (including support for client certificates), support for multiple accounts, DSN, and IPv6 support.