libTISCH is a framework for easy development of multi-touch applications. It contains tools for video processing, calibration, gesture recognition and, most importantly, a GUI toolkit with widgets that utilize the multi-touch gestures detected by the lower layers. It runs on Linux, Mac OS X, and Windows.
The Ecere SDK is a cross-platform toolkit for building software applications. It currently runs on Windows, Linux, Mac OS X (through X11), FreeBSD, and the Android OS. It should run on other Unix platforms with minor testing/tweaking. With the Ecere SDK, you can develop applications once and deploy them on all supported platforms alongside a lightweight runtime environment. It introduces eC, an object oriented language derived from and fully compatible with C, compromising neither runtime performance nor ease of use. A built-in 3D engine supporting both Direct3D and OpenGL is fully integrated.
Faith is a cross-platform C++ graphical application toolkit. It runs natively on Linux/Unix (Xlib) and Windows. It has an API strongly inspired by Qt's and has many features that are expected from a modern toolkit, including a variety of common "widgets", an aesthetically pleasing appearance, and the many critical non-portable components such as anti-aliasing and sockets.