Roundcube Webmail is a browser-based, multilingual IMAP client with an application-like user interface. It provides the full functionality you expect from an email client, including MIME support, address book, and folder manipulation. High extensibility is granted by the plugin API and the user interface is fully skinnable using XHTML and CSS 2.
SOGo is a very fast and scalable modern collaboration suite (or groupware). It offers calendaring, address book management, and a full-featured Webmail client along with resource sharing and permission handling. It also makes use of documented standards (IMAP, CalDAV, CardDAV, etc.) and thereby provides native connectivity (without plugins) to many clients such as Microsoft Outlook, Apple iCal, the iPhone, Mozilla Lightning, and a plethora of mobile devices via SyncML. It can reuse any existing email and database infrastructure, avoiding long hours of site restructuring.