PySite is not a CMS in the traditional sense. Rather, you manage the contents of a Web site via a file manager interface, which gives you access to all settings (pages, styles, plugins, etc.). Compose your pages with Jinja templates, and edit your code comfortably with syntax highlighting in the ACE editor. You may write your stylesheets in Sass and let the integrated compiler write CSS files. PySite also contains a facility to manage virtual mailboxes, in case you maintain your own SMTP and IMAP server, e.g. with Postfix and Dovecot.
GUI Builder is a drag and drop interface for creating WebElement User Interface (WUI) templates that can be used as the foundation of a responsive Wep app. It simplifies the process of designing applications, and encourages separation of the logic and view. It is part of the WebBot Web development framework, which makes it possible to build Web apps in a similar fashion to Qt/KDE apps.
WebBot is a Web development toolset which is designed to sit nicely on top of your existing infrastructure. It is built with a collection of Open Source tools which together enable building Python Web applications the same way native ones are built and running these applications on top of the leading Python frameworks (such as Django and Google's App Engine). As a result, the WebBot framework encourages reuse, concise code, rapid development, and happy developers.