Scheme Note is a Scheme-like music file format and MIDI conversion tool. It takes a text file, which is a representation of a song, loosely tied to a MIDI-like event structure, and outputs a corresponding MIDI file. It is hand-editable for simple songs, and should be very easy to parse for a GUI.
Nyquist is an elegant and powerful language for sound synthesis and music composition. Unlike score languages that tend to deal only with events, or signal processing languages that tend to deal only with signals and synthesis, it handles both in a single integrated system. It is also flexible and easy to use because it is based on an interactive Lisp interpreter. You can design instruments by combining functions (much as you would using the orchestra languages of Music V, cmusic, or Csound). You can call upon these instruments and generate a sound just by typing a simple expression. You can combine simple expressions into complex ones to create a whole composition. It runs under any Unix environment, MacOS, Windows 95, and Windows NT, and it produces sound files as output (or direct audio output under Windows).
WaveSurfer is a sound visualization/manipulation tool for novice and advanced users, with a simple and intuitive user interface. It can be adapted to different tasks, such as speech research and education, speech/sound analysis, and sound annotation/transcription. You can also make more advanced/specialized applications by extending it with custom plugins or embed WaveSurfer components in other applications. Its flexible interface handles many different file formats, and it runs on many flavors of Windows and Unix. It also supports encoding and Unicode with unlimited file size, and more.
The CMU Midi Toolkit (CMT) is a collection of software for writing interactive MIDI software in C. It includes a number of handy utilities along with an application "shell" that provides timing, scheduling, and MIDI interfaces that are portable across DOS, Mac, SGI, and Amiga platforms.