Tux Paint is a simple and entertaining drawing program geared towards young children. It has a simple interface, sound effects, and a cartoon character (Tux, the Linux penguin). Along with drawing brush strokes, lines and shapes, you can also enter text and place "rubber stamp" (or "sticker") images on the picture. Tux Paint is extensible, and could be useful in an educational environment (such as a grammar, elementary, or grade school). It's portable across numerous platforms, and runs well even on slower systems like the Pentium 133MHz.
Ansel is a Horde photo gallery that provides functionality for managing unlimited photo galleries, with thumbnails, paging, EXIF data, and permissions on a per-gallery basis. It also provides a number of features not normally found in Web-based photo galleries, including cropping, resizing, rotating, watermarking, and greyscale effects.
MuseScore lets you notate and compose music easily with your keyboard, your mouse, or a MIDI keyboard. You can print beautifully engraved sheet music or export it as PDF or PNG. You can play your score, transpose it, and save it as audio or MIDI file. MuseScore also supports MusicXML to let you share your composition with other scorewriters. MuseScore is often advertised as a cost effective alternative for Sibelius and Finale.
Stopmotion is an application for creating stop motion animations from images imported from a v4l (or similar) device. The animations can be saved as .sto files and exported as video files. Grabbing of images and video export is plug-in based, so it is easy to use your favourite programs such as mencoder, ffmpeg, dvgrab, and vgrabbj to do the job.
ArahPaint4 is a textile-oriented paint program, mainly for jacquard. It is a simple paint program for raster palette images. It has good tools for drawing images in repetition, support for handling palette images (color reduction, substitution, protected, transparent colors), contour tools, layer support, unlimited undo/redo, support for drawing in aspect ratio (pixels need not be square), a two level grid, and a coordinates display. It is simple, stable, fast, and works well on large images (>8000x8000).