XamimeLT is an email scanner which encapsulates your existing sendmail or Postfix server setup. It scans both incoming and outgoing email. It can scan for email viruses, unwanted file types (eg. EXE, BMP, MPEG) and file names (eg. prettypark.exe), spam, and almost anything you care to search for in an email. It can also be used to scan for text snippets within emails and to insert disclaimers into outbound emails. XamimeLT was formerly known as "Inflex".
PHP Mobile Mail is aimed at mobile professionals who want to use their favorite MUAs (noteably pine or mutt) on their laptop, either in UNIX or Windows (under GNU Gygwin). This lets you work offline. It includes a mail_spooler program, which accepts the output of you MUA and spools (on, or offline). When connected, another process parses through the spool and sends your messages. It is also designed to "fake" using your REAL email address with free services like gmx.net, or mail.yahoo.com, when using their POP and SMTP servers, assuming you have a domain and account that you can control to this degree.