PySite is not a CMS in the traditional sense. Rather, you manage the contents of a Web site via a file manager interface, which gives you access to all settings (pages, styles, plugins, etc.). Compose your pages with Jinja templates, and edit your code comfortably with syntax highlighting in the ACE editor. You may write your stylesheets in Sass and let the integrated compiler write CSS files. PySite also contains a facility to manage virtual mailboxes, in case you maintain your own SMTP and IMAP server, e.g. with Postfix and Dovecot.
Zato is an Enterprise Service Bus (ESB) and app server written by pragmatists for pragmatists. It provides an HA load-balancer, hot-deployment, and hot-reconfiguration almost everywhere (forget server restarts). It has a browser-based GUI, CLI, and API (forget XML configuration). It supports many protocols, industry standards, and data formats, including HTTP, JSON, SOAP, REST, AMQP, JMS WebSphere MQ, ZeroMQ, Redis, SQL, and FTP.