The Apache Open For Business Project is an enterprise automation software project that includes ERP, CRM, E-Business/E-Commerce, SCM, MRP, and CMMS/EAM functions. It is a foundation and starting point for enterprise solutions and can certainly be used out of the box, but is also great for creating specialized applications.
OTRS is a platform independent Web-based help desk system that supports service organization of any kind (e.g. IT service, customer and technical product service, complaint management, public services, etc.) to increase their efficiency. It increases transparency as well as service quality and lowers your total cost of ownership. It has been certified ITIL V3 compatible by PinkVERIFY for incident, problem, change, service asset and configuration, request fulfillment, and knowledge management. Other ITIL processes like service catalog and service level management are supported as well.