Seg3D is a volume editing and processing tool that combines a flexible manual segmentation interface with powerful higher-dimensional image processing and segmentation algorithms from the Insight Toolkit. DICOM, VFF, META, NRRD, and many other volume formats are supported. Users can explore and label image volumes using configurable, orthogonal slice view windows and 3D volume rendering.
The OpenVL library is a framework for working with 3D volumetric datasets. It provides a standard and uniform API to volumetric data access, storage, and processing. It is designed and built to be fast, extensible, flexible, and easy to use. The library is completely open-sourced and encourages contribution. This library is an ideal choice if you want to write applications that deal with 3D volumes.