Bulk Mac Mail is an an application for sending personalized mass email messages. It allows you to use message templates with multiple custom fields from the recipient database inside your messages. Customer lists can be imported from files of any type. Since all messages go through the standard Apple Mail's message delivery framework, they are absolutely indistinguishable from the messages that were actually sent by Apple Mail.
Lamson is an SMTP server adopts a modern Web application framework design. Rather than bizarre flat file "databases" and hashtable stores, Lamson uses anything that Python does to store data, including Django's ORM, web.py's simple database library, Tokyo Tyrant, Lightcloud, Python's Shelve (not recommended), Raw SQLite3, SQLObject, CouchDB, Mongo DB, and SQLAlchemy.
mailxel is a personal mail store and mail client with a focus on the management and organization of high volume mail boxes. The main features are fast search, tagging, GTD inbox management workflow, efficient data storage, address management, automated server-side mail folder organization, and normal mail functionality (send, receive, forward, etc.).
pop3ml is a program to manage mailing lists and newsletters without a local SMTP server. It requires only a simple POP3 email account. It's highly configurable by users. You can subscribe or unsubscribe simply with email messages. There is optional subscription and unsubscription confirmation, subscription moderation, message moderation, digest message mode, parent/children list management, mail scheduling to postpone or repeat a message, a mail filter (with a procmail-like syntax), a message queue for unsent messages, message size check, a command to retrieve messages, bounce detection, message header management, black/white/allow/deny lists, and other functions. There is also a program to test list settings without sending any messages and another program to view and search through stored messages. You can configure it with programs like phpMyAdmin.
OpenSMTPD is an RFC compliant, secure, and simple SMTP server ported from OpenBSD to Linux. It supports the SMTP protocol, including SSL versions for added security, virtual domains, forward files, and external delivery agents like procmail, and can do most of the basic things that other MTA implementations do.
Exim4U is a Web-based user interface and integrated software configuration for the Exim message transfer agent (MTA). Using any modern Web browser, you can use it to manage Exim email domains, user accounts, aliases, forwarders, and much more. Exim4U is a derivative work of the Virtual Exim (Vexim) project.
Sendooway is a multi-user and multi-target ESMTP proxy that acts as mail transfer agent. Instead of configuring SMTP servers and authentication data for every mail identity on every device, it allows you to configure them centrally. Sendooway automatically uses the correct smarthost, logs on with the user's account data, and sends their mail.
S22.Imap is an easy-to-use and well-documented .NET library component for communicating with and receiving electronic mail from an Internet Message Access Protocol (IMAP) servers. It supports IMAP IDLE notifications and IMAP over SSL, allows selective fetching of parts of mail messages, is inherently thread-safe, and is well documented with lots of example code.