Postoffice is a simple SMTP mail server and client written with spam blocking in mind. It provides a greylist to slow down the rate of incoming spam, and can be configured to do antivirus checking on incoming mail either via the sendmail milter protocol or a traditional hard-coded AV program. Postoffice can be configured to deliver mail to accounts inside vm-pop3d-style virtual domains, and it can further be enabled to support AUTH LOGIN for people inside virtual domains, so they can use postoffice as a mail forwarder when replying to mail. Postoffice accepts (and ignores) many of the same command line options that are passed to sendmail, and it comes with the usual crop of sendmail compatable aliases; runq, mailq, newaliases, and sendmail.
Python SRS Library is a Python translation of the Perl reference implementation for SRS (Sender Rewriting Scheme) with easy to install packaging and built-in sendmail integration. SRS is needed when forwarding mail for SMTP authorization schemes that publish which IPs are authorized to send mail from a domain (for example SPF - Sender Policy Framework). It can also detect forged SMTP bounces by signing the return path for outgoing mail.
QUICA is a Web interface to manage various aspects of email administration. Working as a courier-mta frontend, it can make a quick and easy to use email server. Tasks like creating accounts and forwards can be done easily. It manages domains separately, allowing the delegation of each domain to different people. It's a great tool for your customers if you are a service provider, but also works well for a single domain. Quotas for each account are managed, the number of email messages and hard disk space can be controlled accurately. Internationalization is provided (with some languages included) and you can add your own. The interface allows you to delegate the management to non-sysadmins.