PHP Mobile Mail is aimed at mobile professionals who want to use their favorite MUAs (noteably pine or mutt) on their laptop, either in UNIX or Windows (under GNU Gygwin). This lets you work offline. It includes a mail_spooler program, which accepts the output of you MUA and spools (on, or offline). When connected, another process parses through the spool and sends your messages. It is also designed to "fake" using your REAL email address with free services like gmx.net, or mail.yahoo.com, when using their POP and SMTP servers, assuming you have a domain and account that you can control to this degree.
Kolab is a groupware system that provides a comprehensive and flexible solution for workgroups. Email, contacts, and group calendars can be managed via the Web, Windows/Outlook, and Linux/KDE. It supports offline synchronization and full seamless support of mixed client environments because the Kolab-XML storage format is fully open and avoids MAPI/TNEF.
eXtended Account Management System (XAMS) allows Administration of Unix, Web, FTP, DNS, and email accounts to manage a provider's typical userbase. Especially focusing on email account management, it enables you to easily create accounts, set aliases, and delegate domain administration to 2nd party resellers or customers. It uses PHP with MySQL or PostgreSQL as a backend, and is therefore able to manage tons of email accounts independently from your Unix/Linux accounts. Exim for SMTP and Courier for POP/IMAP are fully supported, but postfix, Cyrus, and qmail can be used too.
Tellmatic is a tool to manage and create newsletters for personalized mailing or mass mailing. Addresses and newsletters are stored in groups to handle different user groups and thousands of addresses at a time. SMTP is used for sending the newsletter to your subscribers to make sure you get all error and bounce messages. Bounces can be handled automagically via a small bounce-management module with POP3 access. It also has a small form-editor and statistics. You can import and export your addresses in CSV format.