getmail is intended as a simple, secure, and reliable replacement for fetchmail. It retrieves email (either all messages, or only unread messages) from one or more POP3, SPDS, or IMAP4 servers (with or without SSL) for one or more email accounts, and reliably delivers into qmail-style Maildirs, mboxrd files, or through external MDAs (command deliveries) specified on a per-account basis. getmail also has excellent support for domain (multidrop) mailboxes, including delivering messages to different users or destinations based on the envelope recipient address.
The Courier mail transfer agent (MTA) is an integrated mail/groupware server based on open commodity protocols such as ESMTP, IMAP, POP3, LDAP, SSL, and HTTP. Courier provides ESMTP, IMAP, POP3, Webmail, and mailing list services within a single consistent framework. Individual components can be enabled or disabled at will. Courier implements basic Web-based calendaring and scheduling services integrated in the Webmail module.
Bulk Mailer helps speed the delivery of an email message to many recipients using Sendmail. It's best used in parallel with a mailing list manager such as Majordomo. For input, it takes a file of recipient addresses (one address per line) and a message (with headers already attached) to be sent to the recipients. It sorts the recipient list by reversed domain (so similar ones sort together), splits up the recipients into several groups containing no more than N domains each, creates an SMTP envelope for each group of recipients, and feeds each envelope to sendmail.
PHP Mobile Mail is aimed at mobile professionals who want to use their favorite MUAs (noteably pine or mutt) on their laptop, either in UNIX or Windows (under GNU Gygwin). This lets you work offline. It includes a mail_spooler program, which accepts the output of you MUA and spools (on, or offline). When connected, another process parses through the spool and sends your messages. It is also designed to "fake" using your REAL email address with free services like gmx.net, or mail.yahoo.com, when using their POP and SMTP servers, assuming you have a domain and account that you can control to this degree.