Audiality is a highly scalable and portable audio engine and synthesizer. MIDI files are used in combination with scripting and modular synthesis, to minimize file sizes and maximize flexibility. Audiality can be used as a music and sound effects player in multimedia productions, or as a realtime MIDI synthesizer.
MidiKeys is a little application that displays a piano keyboard onscreen. You can click the keyboard or use the computer keyboard to play MIDI notes. The keyboard window can be made to float on top of other applications and supports transparency. Also, MidiKeys will optionally set up hotkeys for the computer keyboard so you can play notes in other applications (such as a sequencer) without having to switch back to MidiKeys. It works great on a PowerBook!
SynthTest is a somewhat simple application for OS X that allows you to pick a MIDI source, a MusicDevice AudioUnit, and an Effect or MusicEffect AudioUnit to play with. You can open an edit window for both the synth and effect. If they do not have a custom edit GUI, the generic editor view will be used. SynthTest has a reference implementation of preset support for Audio Units. It is primarily intended to be used by Audio Unit developers for testing purposes (the source is available), although it can be great fun to play with all by itself. It is complete enough to be used for live performances.
LiquidMaya is a Maya to Renderman plug-in that handles full Renderman output support with a focus on speed, efficiency, and extensibility. Its features include procedural rib generation, full network rendering support, segmented rib files, a shader assignment interface, and much more. Along with the ability to write full C++ plug-ins, it is incredibly easy to script Liquid with Mel. Liquid was used for the visual effects of the "Lord of the Rings" movie.