BRL-CAD is a powerful constructive solid geometry solid modeling system that includes an interactive geometry editor, ray-tracing support for rendering and geometric analysis, path-tracing for realistic image synthesis, network distributed framebuffer support, and image and signal-processing tools.
Coin is an implementation of Open Inventor. Open Inventor is the de facto standard API for retained-mode 3D graphics programming. Open Inventor has a highly extensible design, and has been designed to allow for rapid development of highly interactive 3D graphics applications in the fields of CAD, engineering, scientific computing, simulation, VRML, and visualization.
Jmol is a Free, Open Source molecule viewer and editor. It is a collaboratively developed visualization and measurement tool for chemical scientists. Jmol is an active project, and there are new features being added to it on a daily basis. Users are encouraged to modify it to fit their needs and to contribute their changes to the project.
The Interverse is the evolution and combination of the Web, chat, instant messaging (IM), and voice communication. It is not just a graphical user interface (GUI), but an immersive user interface (IUI). The Interverse is a virtual universe running on top of the Internet. It uses the Crystal Space 3D engine to render the user's view of the world.
OGRE (Object-Oriented Graphics Rendering Engine) is a class library written in C++ designed to make it easier and more intuitive for developers to produce games and demos utilising 3D hardware. It exposes a number of useful objects allowing you to create and manipulate a 3D environment and render it to your specifications, while removing the unnecessary complexities of the underlying system libraries like Direct3D and OpenGL.
The Interreality project is a collection of Open Source, Free Software projects based on the Virtual Object System (VOS) platform. The goal is to develop a free and open platform for multi-user 3D virtual reality games, applications, and interactive, collaborative 3D virtual spaces. VOS is a powerful and generic network object framework designed to support a variety of high-performance applications. It is the basis for Ter'Angreal, a general-purpose browser application for entering and participating in 3D worlds.
The Chemistry Development Kit (CDK) is a library of Java classes for chemo-, bioinformatics, computational chemistry, and chemometrics. It provides important algorithms like substructure search, SMILES, Gasteiger charges, QSAR descriptor calculation, 3D structure generation, 2D layout and rendering, many IO formats, atom typing, and more.