GNU TeXmacs is a free wysiwyw (what you see is what you want) editing platform with special features for scientists. The software aims to provide a unified and user friendly framework for editing structured documents with different types of content: text, mathematics, graphics, interactive content. TeXmacs can also be used as an interface to many external systems for computer algebra, numerical analysis, and statistics. New presentation styles can be written by the user and new features can be added to the editor using Scheme.
Bigloo is an implementation of the Scheme programming language. It relies on an optimizing compiler from Scheme to C. Bigloo enables connections between Scheme code and C code. It proposes many extensions to Scheme such as a regular parser compiler, an lalr parser compiler, pattern matching, an object layer, etc.
Chicken is a Scheme compiler that translates most of R5RS Scheme into relatively portable C. It supports fully general tail-call recursion, first-class continuations, and has a very flexible and efficient interface to C and C++. Chicken implements several extensions to the Scheme language: lightweight threads, pattern matching macros, dynamic loading of compiled code, and various object-oriented paradigms, such as TinyCLOS, and others. The library system includes hundreds of convenient modules for practical use.
STklos is a free Scheme System conforming to R5RS. The implementation is based on an ad-hoc Virtual Machine. It can also be compiled as a library, so that one can easily embed it in an application. Its features include an efficient and powerful object system based on CLOS, a simple-to-use module system, implementation of the full tower of numbers defined in R5RS, and easy connection to the GTK+ toolkit. STklos is the successor of STk, a Scheme interpreter tightly connected to the Tk toolkit.
Thousand Parsec is a turn-based space empire building game, as well as a framework for creating a similar group of games, which are often called 4X games (eXplore, eXpand, eXploit, and eXterminate). Some examples of games from which Thousand Parsec draws ideas are Reach for the Stars, Stars!, VGA Planets, Master of Orion, and Galactic Civilizations. Unlike commercial alternatives, it is designed for long games supporting universes as large as your computer can handle. It allows a high degree of player customization, and features a flexible technology system where new technologies may be introduced mid-game.
Geiser is a generic Emacs/Scheme interaction mode, featuring an enhanced REPL and a set of minor modes that improve Emacs' basic major mode for Scheme. The main features provided are evaluation of forms in the namespace of the current module, macro expansion, loading of files and modules, namespace-aware identifier completion, automatic documentation, jumping to the definition of an identifier, access to documentation, listings of identifiers exported by a given module, and rudimentary support for debugging. Geiser supports Guile and Racket.
Meep is a free finite-difference time-domain (FDTD) simulation software package to model electromagnetic systems. It supports distributed-memory parallel simulations, nonlinear, anisotropic, and dispersive media, PML absorbing boundaries, and 1D/2D/3D and cylindrical problems. It is completely scriptable from either C++ or a Scheme (GNU Guile) interface.
Halyard is a scriptable multimedia engine with support for video, audio, graphics, and user interaction. It currently runs on Windows, and has a preliminary Macintosh port. It is based on PLT Scheme, wxWidgets, and the Quake 2 Engine. It includes a rudimentary IDE based on Scintilla.