Wine is an implementation of the Windows API on top of X and Unix. It does not require Microsoft Windows, but can use native Windows DLLs if they are available. It provides both a development toolkit for porting Windows source code to Unix as well as a program loader, allowing many unmodified Windows programs to run on x86-based Unixes.
Doom was the classic 3D shoot'em'up game from id Software. PrBoom is a game engine for playing Doom levels, which runs on both Windows and Linux/Unix systems. It uses the SDL graphics library. PrBoom a very faithful Doom port, with great effort taken to be compatible with as many original Doom levels and demos as possible.
Allegro is a multi-platform game library for C/C++ developers that provides many functions for graphics, sounds, player input (keyboard, mouse, and joystick), and timers. It also provides fixed and floating point mathematical functions, 3D functions, file management functions, compressed datafile, and a GUI.
Artekopia Netjuke is a cross-platform Web-based audio streaming jukebox powered by PHP 4 and an increasing choice of databases. MP3, Ogg Vorbis, ASF/WMA, and other music file formats are supported. Artekopia Netjuke aims to enable small organizations or communities run a private "mp3.com-like" Web site to access the music they legitimately own, distribute, or are granted access to. It supports most audio players, language packs, optional file downloads, media protection schemes, multi-level security, shared and private playlists, random playlists, images, etc. It also features an unusual, easy-to-use installer module to get you started in minutes.
Tux Paint is a simple and entertaining drawing program geared towards young children. It has a simple interface, sound effects, and a cartoon character (Tux, the Linux penguin). Along with drawing brush strokes, lines and shapes, you can also enter text and place "rubber stamp" (or "sticker") images on the picture. Tux Paint is extensible, and could be useful in an educational environment (such as a grammar, elementary, or grade school). It's portable across numerous platforms, and runs well even on slower systems like the Pentium 133MHz.
The Noble Ape Simulation is a collection of a number of autonomous simulation components including a landscape simulation, biological simulation, weather simulation, sentient creature (Noble Ape) simulation, and a simple intelligent-agent scripting language (ApeScript). Noble Ape also contains a social simulation where the Noble Apes can be tracked in terms of social groups and also over many generations to explain social phenomenon to users looking to study this kind of interaction. It has been in development for more than a fifteen years.