GNU TeXmacs is a free wysiwyw (what you see is what you want) editing platform with special features for scientists. The software aims to provide a unified and user friendly framework for editing structured documents with different types of content: text, mathematics, graphics, interactive content. TeXmacs can also be used as an interface to many external systems for computer algebra, numerical analysis, and statistics. New presentation styles can be written by the user and new features can be added to the editor using Scheme.
Calc is arbitrary precision arithmetic system that uses a C-like language. It's useful as a calculator, an algorithm prototype, and as a mathematical research tool. More importantly, calc provides a machine-independent means of computation. Calc comes with a rich set of builtin mathematical and programmatic functions.
Genius is an arbitrary precision integer and multiple precision floating point calculator. It includes its own programming language similar in some aspects to C, bc, or Pascal. It can deal with rational numbers and complex numbers. It has matrix support as well. It uses the gmp library so it is very fast for calculations of large numbers. It has a command line and a GNOME interface. The GNOME interface supports plotting functions and 3D surfaces.
Isabelle is a popular generic theorem prover developed at Cambridge University and TU Munich. Existing logics like Isabelle/HOL provide a theorem proving environment ready to use for sizable applications. Isabelle may also serve as framework for rapid prototyping of deductive systems. It comes with a large library including Isabelle/HOL (classical higher-order logic), Isabelle/HOLCF (Scott's Logic for Computable Functions with HOL), Isabelle/FOL (classical and intuitionistic first-order logic), and Isabelle/ZF (Zermelo-Fraenkel set theory on top of FOL).
OBJ3 is a program specification and proof system based on order sorted equational logic. It has been successfully used for research and teaching in software design and specification, rapid prototyping, theorem proving, user interface design, and hardware verification, among other things. It was the first language to implement parameterized programming and its module system influenced the designs of the Ada, C++, and ML module systems.
Cactus is a general, modular, parallel environment for solving systems of partial differential equations. The code has been developed over many years by a large international collaboration of numerical relativity and computational science research groups and can be used to provide a portable platform for solving any system of partial differential equations.