Quassel IRC is a modern, cross-platform, distributed IRC client, meaning that one or more clients can attach to and detach from a central core, much like the popular combination of screen and a text-based IRC client, but graphical. In addition to this unique feature, it aims to be a comfortable chatting program.
The SeaMonkey project is a community effort to develop an all-in-one Internet application suite. It contains an Internet browser, email and newsgroup client with an included Web feed reader, HTML editor, IRC chat, and Web development tools, and is sure to appeal to advanced users, Web developers, and corporate users. It uses much of the Mozilla source code powering such successful siblings as Firefox, Thunderbird, Camino, Sunbird, and Miro.
ngIRCd is a portable IRC daemon written from scratch. It is easy to configure, supports server links (even with original ircds) and runs on hosts with changing IP addresses (such as dial-in networks). Currently supported platforms are AIX, A/UX, Darwin/Mac OS X, FreeBSD, HP-UX, IRIX, Linux, NetBSD, SunOS/Solaris, and Windows with Cygwin.
Smuxi is an irssi-inspired, flexible, user-friendly, and cross-platform IRC client for sophisticated users. Smuxi is based on the client-server model: The core application (engine) can be placed onto a server which is connected to the Internet around-the-clock; one or more frontends then connect to the core. This allows the connection to IRC to be kept up even when all frontends have been closed. The combination of screen and irssi served as the example for this architecture. Smuxi also supports the regular single application mode. This behaves like a typical IRC client; it doesn't need separate core management and utilizes a local engine that is used by the local frontend client.
libircclient is a small but powerful library that implements the client-server IRC protocol. It is designed to be small, fast, portable, and compatible with RFC standards and most IRC clients. It includes multi-threading support, sync and async interfaces, CTCP and DCC support, and color support. Good documentation and examples are available.
BitchX is the premiere IRC (Internet Relay Chat) client. It originally was a modified version of the popular ircII client, and the features were eventually merged into the EPIC IRC client. The current development is aimed at merging the client back to a current branch of EPIC and bringing compatibility and stability back to the client, while bringing the features that are BitchX into a new client.
ircproxy is an Internet Relay Chat Proxy, which works as a layer between your IRC client and the IRC server. It features bouncer capability and has more features, flexibility, and configuration options than other tools. It also includes an option to use the system password list instead of requiring a separate password database.