msmtp is an SMTP client with a sendmail compatible interface. It can be used with Mutt and other MUAs. It forwards messages to an SMTP server which does the delivery. Features include various SMTP AUTH methods, TLS/SSL-encrypted connections (including support for client certificates), support for multiple accounts, DSN, and IPv6 support.
Cerb is a fast and flexible Web-based platform for business collaboration and automation. It helps you remember anything about anyone, collaborate from anywhere, deftly reply to a flood of email, automate, stay informed, capture feedback, track time, flag opportunities, manage tasks, share expert knowledge, and otherwise execute efficiently.
The SeaMonkey project is a community effort to develop an all-in-one Internet application suite. It contains an Internet browser, email and newsgroup client with an included Web feed reader, HTML editor, IRC chat, and Web development tools, and is sure to appeal to advanced users, Web developers, and corporate users. It uses much of the Mozilla source code powering such successful siblings as Firefox, Thunderbird, Camino, Sunbird, and Miro.
fdm (fetch and deliver mail) is a simple, lightweight replacement for mail fetching, filtering, and delivery programs such as fetchmail and procmail. It can fetch using POP3, POP3S, IMAP, IMAPS, or stdin, and deliver to a pipe, file, maildir, mbox, or SMTP server, based on a set of regexps. It can be used for both single user and multiuser setups, and is designed with privilege separation when running as root.
eSAV is an email sender address verification console utility for Linux/FreeBSD. It opens an SMTP connection to the sender's mail server and emulates an error return message to the sender without actually completing the transaction. It's an easy way to check if an email address is alive.