OpenOTP Authentication Plugin SugarCRM enables strong two factor authentication for admins and users. It displays an overlay on a Challenge-Response session, after filling in the username and password. It supports global and per-user settings configurations. It will transparently handle any OpenOTP Login Mode, including LDAP only, OTP only, and LDAP+OTP.
Brimbox is a database system that was designed to bridge the gap between spreadsheets and custom databases. It is intended to be an alternative to Access and Filemaker. Although Brimbox has its own modular approach, it is customizable in the spirit of Wordpress, though it is a database interface and not a CMS.
eLabFTW is an electronic laboratory notebook system. Once installed on a server, every member of a lab can write up their experiments, upload files, manage a database of products (antibodies, chemicals, siRNA, papers, or whatever you want). It was created with usability and security in mind, is very easy to use, and has a long list of features specific to research life.