msg-rpc provides bidirectional RPC support over a simple message interface such as WebSocket. Tere are WebSocket examples based on socket.io and sockjs. It just has a simple sendMessage/onMessage interface, with no other dependencies. It supports not only normal RPC, but also RPC Service, which makes RPC pushable (i.e. the server can also send a request to the client and expect some kind of response).
eLabFTW is an electronic laboratory notebook system. Once installed on a server, every member of a lab can write up their experiments, upload files, manage a database of products (antibodies, chemicals, siRNA, papers, or whatever you want). It was created with usability and security in mind, is very easy to use, and has a long list of features specific to research life.
Roosevelt is a Web framework for Node.js which uses Teddy for HTML templating and LESS for CSS preprocessing. Built on Express, Roosevelt is designed to abstract all the crusty boilerplate necessary to build a typical Express app, sets sane defaults with mechanisms for override, and provides a uniform MVC structure for your app.