Inkscape is a drawing tool with capabilities similar to Illustrator, Freehand, and CorelDraw that uses the W3C standard scalable vector graphics format (SVG). The supported SVG features include basic shapes, paths, text, markers, clones, alpha blending, transforms, gradients, and grouping. In addition, it supports Creative Commons meta-data, node-editing, layers, complex path operations, text-on-path, and SVG XML editing. It also imports several formats like EPS, Postscript, JPEG, PNG, BMP, and TIFF and exports PNG as well as multiple vector-based formats.
Sketsa SVG Editor is a vector drawing application based on SVG. It allows users to create vector graphics that can be scaled and printed at any resolution, without losing detail or clarity. It features various tools for optimizing content creation, and includes a property palette, a DOM editor, a source editor, a resource editor, SVG-specific shape tools, transformation tools, and additional illustration tools. It uses SVG as its native file format.
Evolvotron is an interactive "generative art" application to evolve images/textures/patterns through an iterative process of random mutation and user-selection driven evolution. If you like lava lamps, and never got tired of the Mandelbrot set, this could be the software for you. It's implemented using Qt, and is multithreaded.
Grafx2 is a bitmap paint program that allows you to draw in more than 60 video resolutions (from 320x200 to 1024x768, including most of the standard Amiga resolutions: 320x256, 320x512, 640x256, 640x512, and more, provided your video card knows how to handle them). Its layout is not very different from the famous Deluxe Paint or Brilliance, so it will be quite easy to handle it if you know at least one of these programs.
Raster3D is a set of powerful tools for generating high quality raster images of proteins or other molecules. The core program renders spheres, triangles, cylinders, and quadric surfaces with specular highlighting, Phong shading, and shadowing. It uses an efficient software Z-buffer algorithm that is independent of any graphics hardware.