The SeaMonkey project is a community effort to develop an all-in-one Internet application suite. It contains an Internet browser, email and newsgroup client with an included Web feed reader, HTML editor, IRC chat, and Web development tools, and is sure to appeal to advanced users, Web developers, and corporate users. It uses much of the Mozilla source code powering such successful siblings as Firefox, Thunderbird, Camino, Sunbird, and Miro.
Cerb is a fast and flexible Web-based platform for business collaboration and automation. It helps you remember anything about anyone, collaborate from anywhere, deftly reply to a flood of email, automate, stay informed, capture feedback, track time, flag opportunities, manage tasks, share expert knowledge, and otherwise execute efficiently.
msmtp is an SMTP client with a sendmail compatible interface. It can be used with Mutt and other MUAs. It forwards messages to an SMTP server which does the delivery. Features include various SMTP AUTH methods, TLS/SSL-encrypted connections (including support for client certificates), support for multiple accounts, DSN, and IPv6 support.
ADJE WebMail is a set of Perl CGI scripts which provide a Web interface to existing email accounts on any POP3-compliant email server. The software provides a complete interface, including encoding/decoding attachments, email and URL markup in received emails, and an address book for each user.
PHP Mobile Mail is aimed at mobile professionals who want to use their favorite MUAs (noteably pine or mutt) on their laptop, either in UNIX or Windows (under GNU Gygwin). This lets you work offline. It includes a mail_spooler program, which accepts the output of you MUA and spools (on, or offline). When connected, another process parses through the spool and sends your messages. It is also designed to "fake" using your REAL email address with free services like gmx.net, or mail.yahoo.com, when using their POP and SMTP servers, assuming you have a domain and account that you can control to this degree.