pLauncher allows you to centralize all of your emulator/ROM launching needs. It is open ended enough to allow the launching of any emulator (xmame, snes9x, xmess, vgb, dgen, WINE, etc.) and its ROMS/binaries.
Bordeaux is a Wine GUI configuration manager that runs winelib applications. It also supports installation of third party utilities, installation of applications and games, and the ability to use custom configurations.