spim is a self-contained software simulator for running R2000/R3000 assembly language programs. It reads and can immediately execute files containing assembly language code. spim also provides a debugger and simple set of operating system services. spim provides both a simple, textual interface and a fancier, graphical interface. The package includes complete source code and documentation.
The Intel Software Development Emulator is a functional emulator for new and upcoming instruction set extensions. The emulator is based on the Pin dynamic binary instrumentation system (and XED). It emulates the new instructions in the SSE4, AES, PCLMULQDQ, and RTM, BMI1, and BMI2 Intel AVX, AVX2, and AVX512 instruction set extensions. This allows developers to gain familiarity with Intel's upcoming instruction set extensions.
Wine is an implementation of the Windows API on top of X and Unix. It does not require Microsoft Windows, but can use native Windows DLLs if they are available. It provides both a development toolkit for porting Windows source code to Unix as well as a program loader, allowing many unmodified Windows programs to run on x86-based Unixes.
MDK (MIX Development Kit) provides tools for developing and executing, in a MIX virtual machine, MIXAL programs. The MIX is Donald Knuth's mythical computer, described in the first volume of The Art of Computer Programming, which is programmed using MIXAL, the MIX assembly language. MDK includes a MIXAL assembler (mixasm), a MIX virtual machine (mixvm) with a command line interface, a Guile-based virtual machine (mixguile), a GTK+ based GUI (gmixvm), and a mixvm-Emacs interface (mixvm.el). MDK utilities are extensible using Scheme.