Geiser is a generic Emacs/Scheme interaction mode, featuring an enhanced REPL and a set of minor modes that improve Emacs' basic major mode for Scheme. The main features provided are evaluation of forms in the namespace of the current module, macro expansion, loading of files and modules, namespace-aware identifier completion, automatic documentation, jumping to the definition of an identifier, access to documentation, listings of identifiers exported by a given module, and rudimentary support for debugging. Geiser supports Guile and Racket.
Pymacs is a powerful tool which, once started from Emacs, allows both-way communication between Emacs Lisp and Python. Pymacs in intended for using Python as an extension language for Emacs rather than the other way around, and this asymmetry is reflected in some design choices. Within Emacs Lisp code, one may load and use Python modules. Python functions may themselves use Emacs services and handle Emacs Lisp objects kept in Emacs Lisp space.