epydoc.el is an Emacs LISP program to write Epydoc documentation comments. It supports forrow functions. epydoc-insert-file-comment inserts file comments and @file, @author, and @copyright automatically. epydoc-insert-function-comment inserts function comments and @param/@return automatically. epydoc.el is based on Tom Emerson's doxygen.el.
Pymacs is a powerful tool which, once started from Emacs, allows both-way communication between Emacs Lisp and Python. Pymacs in intended for using Python as an extension language for Emacs rather than the other way around, and this asymmetry is reflected in some design choices. Within Emacs Lisp code, one may load and use Python modules. Python functions may themselves use Emacs services and handle Emacs Lisp objects kept in Emacs Lisp space.