Trojita is a Qt IMAP email client. It is a pure Qt4 application with no additional dependencies. It has a robust IMAP core implemented using Qt's Model-View framework. Standards compliance is a design goal. It has support for bandwidth-saving mode aimed at mobile users with expensive connections. In addition to the usual SSL/TLS connections, the server can be accessed via SSH. It has on-demand body part loading, offline IMAP support, and safe dealing with HTML mail (actually more robust than Thunderbird's).
SpamCheetah is a network-level spam filtering solution built around OpenBSD greylisting, tarpit, and blacklisting. It comes with a Web interface and requires zero administration. It does not allow spam to even land in your network, thus saving you precious bandwidth. It does not have the 'false positives' problem of losing legitimate mail.
mu is a collection of utilities for maildirs, in particular for indexing and searching them. mu fills a database with information about your emails, which can then be queried using an easy query language. It can work stand-alone or be integrated with a mail client. It also provides an emacs-based email client ("mu4e") and bindings for Guile/Scheme.