mu is a collection of utilities for maildirs, in particular for indexing and searching them. mu fills a database with information about your emails, which can then be queried using an easy query language. It can work stand-alone or be integrated with a mail client. It also provides an emacs-based email client ("mu4e") and bindings for Guile/Scheme.
SpamCheetah is a network-level spam filtering solution built around OpenBSD greylisting, tarpit, and blacklisting. It comes with a Web interface and requires zero administration. It does not allow spam to even land in your network, thus saving you precious bandwidth. It does not have the 'false positives' problem of losing legitimate mail.
tkpg is a program that provides a GUI front end to Philip Zimmermann's Pretty Good Privacy (PGP) public-key encryption system and also the GNU Privacy Guard (GnuPG/gpg) implementation. It utilizes the Clipboard Selection heavily to ease moving pgp-processed text both to and from any of your applications (such as mail reader, news reader, and editor). This removes the need to select the output text by hand or by typing in a filename, since it is usually placed in the Selection automatically for you.