mu is a collection of utilities for maildirs, in particular for indexing and searching them. mu fills a database with information about your emails, which can then be queried using an easy query language. It can work stand-alone or be integrated with a mail client. It also provides an emacs-based email client ("mu4e") and bindings for Guile/Scheme.
SpamCheetah is a network-level spam filtering solution built around OpenBSD greylisting, tarpit, and blacklisting. It comes with a Web interface and requires zero administration. It does not allow spam to even land in your network, thus saving you precious bandwidth. It does not have the 'false positives' problem of losing legitimate mail.
libquickmail is a library intended to give C/C++ developers a quick and easy way to send email from their applications. It supports multiple To/Cc/Bcc recipients and multiple MIME attachments without size limitation. It uses libcurl for SMTP communication, but a light version is also included without the libcurl dependancy. The library can also be used to just create a multipart MIME message body. It also comes with a command line application for sending mail (with optional attachments).