Quassel IRC is a modern, cross-platform, distributed IRC client, meaning that one or more clients can attach to and detach from a central core, much like the popular combination of screen and a text-based IRC client, but graphical. In addition to this unique feature, it aims to be a comfortable chatting program.
Ace Operator enables live click to chat service between company representatives and customers from the company Web site. It allows customers to contact live agents at the click of a button, engage in interactive chat-based conversation, and exchange information using multimedia content. It is an application for support and any kind of customer services over the Web.
The SeaMonkey project is a community effort to develop an all-in-one Internet application suite. It contains an Internet browser, email and newsgroup client with an included Web feed reader, HTML editor, IRC chat, and Web development tools, and is sure to appeal to advanced users, Web developers, and corporate users. It uses much of the Mozilla source code powering such successful siblings as Firefox, Thunderbird, Camino, Sunbird, and Miro.
NoxBot is a modular IRC bot that uses the platform independence of PHP. NoxBot is easy to use and features many commands that can be given to the bot over IRC. There are the many available modules. If NoxBot does not provide exactly what you need, then it can be easily implemented as a module. NoxBot tries to stay as RFC-complaint as possible. Some of its features include authentication, module management, a help system, multi-lingual support, timers, a storage system that separates modules, and many more.