Euphoria is a simple, flexible, easy-to-learn programming language. It lets you quickly and easily develop programs for Windows, Linux, FreeBSD, NetbSD, OpenBSD, and Mac OS X. Although Euphoria provides subscript checking, uninitialized variable checking, and numerous other run-time checks, it is extremely fast and has the ability to compile to transparently compile native executables via C code.
MLton is a whole-program optimizing Standard ML compiler. It generates standalone executables with excellent runtime performance, supports the full SML 97 language, and has a complete basis library. It also has a fast C FFI, source-level time and allocation profiling, and many useful libraries.
Steel Bank Common Lisp is a development environment for Common Lisp, with excellent support for the ANSI standard: garbage collection, lexical closures, powerful macros, strong dynamic typing, incremental compilation, and the famous Common Lisp Object System (multimethods and all). It also includes many extensions, such as native threads, socket support, a statistical profiler, programmable streams, and more. These are all available through an integrated, interactive native compiler which feels like an interpreter. SBCL is unique in being a multiplatform native compiler which bootstraps itself completely from source, using a C compiler and any other ANSI Common Lisp implementation.
nwcc is a C compiler for Unix systems. It targets Linux, Mac OS X, BSD, and Solaris on 80x86 (with nasm and gas), Linux, Mac OS X, and FreeBSD on AMD64 (with yasm and gas), Solaris and Linux on SPARC (64-bit), AIX and Linux on PowerPC (32- and 64-bit), and IRIX on MIPS (64-bit). Cross-compilation is also supported. It doesn't feature any software development support beyond plain compilation.