ADJE WebMail is a set of Perl CGI scripts which provide a Web interface to existing email accounts on any POP3-compliant email server. The software provides a complete interface, including encoding/decoding attachments, email and URL markup in received emails, and an address book for each user.
PHP Mobile Mail is aimed at mobile professionals who want to use their favorite MUAs (noteably pine or mutt) on their laptop, either in UNIX or Windows (under GNU Gygwin). This lets you work offline. It includes a mail_spooler program, which accepts the output of you MUA and spools (on, or offline). When connected, another process parses through the spool and sends your messages. It is also designed to "fake" using your REAL email address with free services like gmx.net, or mail.yahoo.com, when using their POP and SMTP servers, assuming you have a domain and account that you can control to this degree.
@1 Helpdesk XP Perl is a very powerful Web-based helpdesk system. It supports file attachments, hidden remarks, priority marking, etc. Unlike other similar products, this script does not use the conventional "assign/completed" method to close past tickets. Instead, it uses an intelligent method to sort/rank inquiry tickets. You can even tell whether your replies have been read by the visitors.
Quassel IRC is a modern, cross-platform, distributed IRC client, meaning that one or more clients can attach to and detach from a central core, much like the popular combination of screen and a text-based IRC client, but graphical. In addition to this unique feature, it aims to be a comfortable chatting program.