CMUCL is a free, high performance implementation of the Common Lisp programming language which runs on most major Unix platforms. It mainly conforms to the ANSI Common Lisp standard. CMUCL provides a sophisticated native code compiler; a powerful foreign function interface; an implementation of CLOS; the Common Lisp Object System; which includes multimethods and a metaobject protocol; a source-level debugger and code profiler; and an Emacs-like editor implemented in Common Lisp. CMUCL is maintained by a team of volunteers collaborating over the Internet, and is mostly in the public domain.
Steel Bank Common Lisp is a development environment for Common Lisp, with excellent support for the ANSI standard: garbage collection, lexical closures, powerful macros, strong dynamic typing, incremental compilation, and the famous Common Lisp Object System (multimethods and all). It also includes many extensions, such as native threads, socket support, a statistical profiler, programmable streams, and more. These are all available through an integrated, interactive native compiler which feels like an interpreter. SBCL is unique in being a multiplatform native compiler which bootstraps itself completely from source, using a C compiler and any other ANSI Common Lisp implementation.
Allegro Common Lisp is a full ANSI Common Lisp (1994) implementation. It contains many extensions, including 32- and 64-bit native compilation, efficient built-in memory management, foreign functions (for interfacing with other languages), multiprocessing, UNICODE and locale support, XML/HTML parsers, a Web client and server, GTK+ interface (1.2 and 2.0), Java interface, OLE interface (Windows only), profiler, regular expressions, an XML RPC implementation, native Lisp RPC, sockets, DLL and shared library support, and more.
Charlemagne is a versatile genetic programming application. It includes a commandline client and an interactive console mode. It is written in Python and Lisp, and is user extensible to some degree in both languages. It features built-in input-output mapping support and provides the ability to define complex fitness calculations in Lisp or Python.