Makeflow is a workflow engine for executing large complex applications on clusters, clouds, and grids. It can be used to drive several different distributed computing systems, including Condor, SGE, and the included Work Queue system. It does not require a distributed filesystem, so you can use it to harness whatever collection of machines you have available. It is typically used for scaling up data-intensive scientific applications to hundreds or thousands of cores.
The Scalable Assembler at Notre Dame (SAND) replaces the early stages of the Celera Assembler with scalable versions that can run on collections of commodity computers. By harnessing clusters, clouds, grids, or just random machines in your office, many bioinformatics tasks can be reduced from weeks or months down to minutes or hours.