Gaim for Qtopia is an official port of the Gaim instant messenger. It is a multi-protocol instant messaging client for the Qtopia and OPIE embedded environments, compatible with the AIM (using the Oscar protocols), ICQ, MSN Messenger, Yahoo!, IRC, Jabber, Gadu-Gadu, Napster, and Trepia networks.
Smuxi is an irssi-inspired, flexible, user-friendly, and cross-platform IRC client for sophisticated users. Smuxi is based on the client-server model: The core application (engine) can be placed onto a server which is connected to the Internet around-the-clock; one or more frontends then connect to the core. This allows the connection to IRC to be kept up even when all frontends have been closed. The combination of screen and irssi served as the example for this architecture. Smuxi also supports the regular single application mode. This behaves like a typical IRC client; it doesn't need separate core management and utilizes a local engine that is used by the local frontend client.
NetIRC2 is an easy-to-use .NET IRC client library. It supports all major features relevant to making a chat client or bot. It has full support for synchronization contexts. You can use it from a Windows Forms or WPF GUI thread and chat events will be automatically dispatched, allowing you to completely ignore multithreading. It uses byte arrays internally, so mixed encodings can be handled. The IrcClient class can even be used as a component in the Forms Designer. Because it speeds up connect times with some IRC servers, an Ident server is included as well.