Thunderbird is a total redesign of the Mozilla mail component to produce a cross-platform, stand-alone mail application using the XUL user interface language. It has many new features, among them the ability to customize your toolbars the way you want them. a new look and feel with a large number of downloadable themes which alter the appearance of the client, and the ability to add UI extensions.
Tine 2.0 is a Web-based groupware solution that focuses on usability and correctness. To achieve these goals, the project uses usability experts and covers most of the code by unit tests. It contains support for contacts, tasks, calendar, email, CRM, VoIP integration, a time tracker, ActiveSync, and a flexible rights management system.
adx is a minimalistic but massively Web-enabled address book that runs completely in your Web browser. It's OS-independent and supports comprehensive details for each contact entry, including user identifiers and profiles for Skype, Twitter, Flickr, Delicious, Facebook, LinkedIn, studiVZ, instant messengers, etc. It supports the hCard and XFN microformats.