BRL-CAD is a powerful constructive solid geometry solid modeling system that includes an interactive geometry editor, ray-tracing support for rendering and geometric analysis, path-tracing for realistic image synthesis, network distributed framebuffer support, and image and signal-processing tools.
Coin is an implementation of Open Inventor. Open Inventor is the de facto standard API for retained-mode 3D graphics programming. Open Inventor has a highly extensible design, and has been designed to allow for rapid development of highly interactive 3D graphics applications in the fields of CAD, engineering, scientific computing, simulation, VRML, and visualization.
The Interreality project is a collection of Open Source, Free Software projects based on the Virtual Object System (VOS) platform. The goal is to develop a free and open platform for multi-user 3D virtual reality games, applications, and interactive, collaborative 3D virtual spaces. VOS is a powerful and generic network object framework designed to support a variety of high-performance applications. It is the basis for Ter'Angreal, a general-purpose browser application for entering and participating in 3D worlds.
The Chemistry Development Kit (CDK) is a library of Java classes for chemo-, bioinformatics, computational chemistry, and chemometrics. It provides important algorithms like substructure search, SMILES, Gasteiger charges, QSAR descriptor calculation, 3D structure generation, 2D layout and rendering, many IO formats, atom typing, and more.
LiquidMaya is a Maya to Renderman plug-in that handles full Renderman output support with a focus on speed, efficiency, and extensibility. Its features include procedural rib generation, full network rendering support, segmented rib files, a shader assignment interface, and much more. Along with the ability to write full C++ plug-ins, it is incredibly easy to script Liquid with Mel. Liquid was used for the visual effects of the "Lord of the Rings" movie.