Release Notes: This release adds a method to compute column-specific pseudocounts in PSI-BLAST. It refactors the grid services library. It adds unit test framework and error logging for all File API classes. It fixes pthread support on IRIX. It enhances support of XML serialization. It fixes support for Sybase. It adds support for smaller lookup tables for small queries. It adds an API to retrieve GenBank loader statistics. It has assorted other enhancements, speedups, and bugfixes.