Blossoc is a linkage disequilibrium association mapping tool that attempts to build (perfect) genealogies for each site in the input, score these according to non-random clustering of affected individuals, and judge high-scoring areas as likely candidates for containing disease affecting variation. Building the local genealogy trees is based on a number of heuristics that are not guaranteed to build true trees, but have the advantage over more sophisticated methods of being extremely fast. Blossoc can therefore handle much larger data sets than more sophisticated tools, but at the cost of sacrificing some accuracy.
|Tags||Scientific/Engineering Bioinformatics Medical Science|
|Operating Systems||OS Independent Unix|
Release Notes: The requested Quantitative traits feature was added.
Release Notes: This version is a port to the new SNPFile format version 2.0.
Release Notes: This version adds support for unphased genotype data through a perfect-phylogeny haplotyping algorithm. If enabled, the release will also support the SNPfile binary format.
Release Notes: This version adds some algorithmic speedups to the permutation testing.
Release Notes: This version provides functionality for quantitative trait mapping and for mapping pairs of genes in presence of epistatsis.