Projects / Blossoc

Blossoc

Blossoc is a linkage disequilibrium association mapping tool that attempts to build (perfect) genealogies for each site in the input, score these according to non-random clustering of affected individuals, and judge high-scoring areas as likely candidates for containing disease affecting variation. Building the local genealogy trees is based on a number of heuristics that are not guaranteed to build true trees, but have the advantage over more sophisticated methods of being extremely fast. Blossoc can therefore handle much larger data sets than more sophisticated tools, but at the cost of sacrificing some accuracy.

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Recent releases

  •  09 Apr 2010 03:43

    Release Notes: The requested Quantitative traits feature was added.

    •  14 Feb 2008 21:50

      Release Notes: This version is a port to the new SNPFile format version 2.0.

      •  03 Jul 2007 14:57

        Release Notes: This version adds support for unphased genotype data through a perfect-phylogeny haplotyping algorithm. If enabled, the release will also support the SNPfile binary format.

        •  04 Dec 2006 07:16

          Release Notes: This version adds some algorithmic speedups to the permutation testing.

          •  12 Nov 2006 12:59

            Release Notes: This version provides functionality for quantitative trait mapping and for mapping pairs of genes in presence of epistatsis.

            Recent comments

            17 Oct 2006 01:48 mailund_birc

            Method published in BMC Bioinformatics
            The association mapping method underlying Blossoc has now been published in BMC Bioinformatics, as:


            Whole genome association mapping by incompatibilities and local perfect phylogenies

            T. Mailund, S. Besenbacher, and M.H. Schierup

            BMC Bioinformatics 2006 7(454). doi:10.1186/1471-2105-7-454.

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